cimascience

Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond

ABSTRACT A major finding—that (–)-trans-D9 -tetrahydrocannabinol (D9 -THC) is largely responsible for the psychotropic effects of cannabis—prompted research in the 1970s and 1980s that led to the discovery that this plant cannabinoid acts through at least two types of cannabinoid receptor, CB1 and CB2, and that D9 -THC and other compounds that target either or …

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