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Palmitoylethanolamide powder: The Miracle Molecule for chronic and neuropathic pain

Palmitoylethanolamide (PEA) is a molecule that has been studied extensively in recent years. This natural compound is produced by our body and has been shown to have beneficial effects on chronic pain, inflammation, and epilepsy. The PEA molecule can be used as a potent analgesic drug for the treatment of chronic pain conditions like arthritis, …

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Dietary Supplements that boost anandamide levels in your body

Are there any anandamide supplements out there? It’s already known that using weed leads to blissful feelings. Studies reveal that THC and CBD bind to cannabinoid receptors, specifically the CB1 and CB2 receptors leading to psychological and physiological outcomes. The CB1 and CB2 receptors make up the body’s endocannabinoid system, aka the ECS. The ECS …

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Neuroprotective effects of anandamide and its analogs

Anandamide, known as AEA for short, plays a very important role in neuroprotection through CB1 receptor and CB2 receptor, or CB1/CB2-independent pathways. There are three kinds of popular anandamide analogs on the market, namely methylfluorophosphonate, fatty acid ethanolamides and lipoamino acids. Anandamide analogs have very similar bioactivity and chemical molecule framework as AEA, however their …

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Biosynthetic Pathways of the Endocannabinoid Anandamide

Anandamide (= N-arachidonoylethanolamine) is the first discovered endocannabinoid, and belongs to the class of bioactive, long-chain N-acylethanolamines (NAEs). In animal tissues, anandamide is principally formed together with other NAEs from glycerophospholipid by two successive enzymatic reactions: 1) N-acylation of phosphatidylethanolamine to generate N-acylphosphatidylethanolamine (NAPE) by Ca2þ-dependent N-acyltransferase; 2) release of NAE from NAPE by a …

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Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond

ABSTRACT A major finding—that (–)-trans-D9 -tetrahydrocannabinol (D9 -THC) is largely responsible for the psychotropic effects of cannabis—prompted research in the 1970s and 1980s that led to the discovery that this plant cannabinoid acts through at least two types of cannabinoid receptor, CB1 and CB2, and that D9 -THC and other compounds that target either or …

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