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The rise and fall of anandamide: processes that control synthesis, degradation, and storage

Abstract Anandamide is a chemical compound that can be found in the human body. It was first discovered after being derived from arachidonic acid-containing membrane lipids and has many biological functions, including pain relief, appetite suppression, anxiety reduction as well as memory improvement; however, its most significant effect on humans may come through its ability …

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Palmitoylethanolamide powder: The Miracle Molecule for chronic and neuropathic pain

Palmitoylethanolamide (PEA) is a molecule that has been studied extensively in recent years. This natural compound is produced by our body and has been shown to have beneficial effects on chronic pain, inflammation, and epilepsy. The PEA molecule can be used as a potent analgesic drug for the treatment of chronic pain conditions like arthritis, …

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Dietary Supplements that boost anandamide levels in your body

Are there any anandamide supplements out there? It’s already known that using weed leads to blissful feelings. Studies reveal that THC and CBD bind to cannabinoid receptors, specifically the CB1 and CB2 receptors leading to psychological and physiological outcomes. The CB1 and CB2 receptors make up the body’s endocannabinoid system, aka the ECS. The ECS …

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Neuroprotective effects of anandamide and its analogs

Anandamide, known as AEA for short, plays a very important role in neuroprotection through CB1 receptor and CB2 receptor, or CB1/CB2-independent pathways. There are three kinds of popular anandamide analogs on the market, namely methylfluorophosphonate, fatty acid ethanolamides and lipoamino acids. Anandamide analogs have very similar bioactivity and chemical molecule framework as AEA, however their …

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Biosynthetic Pathways of the Endocannabinoid Anandamide

Anandamide (= N-arachidonoylethanolamine) is the first discovered endocannabinoid, and belongs to the class of bioactive, long-chain N-acylethanolamines (NAEs). In animal tissues, anandamide is principally formed together with other NAEs from glycerophospholipid by two successive enzymatic reactions: 1) N-acylation of phosphatidylethanolamine to generate N-acylphosphatidylethanolamine (NAPE) by Ca2þ-dependent N-acyltransferase; 2) release of NAE from NAPE by a …

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