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Palmitoylethanolamide (PEA) is a molecule that has been studied extensively in recent years. This natural compound is produced by our body and has been shown to have beneficial effects on chronic pain, inflammation, and epilepsy. The PEA molecule can be used as a potent analgesic drug for the treatment of chronic pain conditions like arthritis, …

Palmitoylethanolamide powder: The Miracle Molecule for chronic and neuropathic pain Read More »

The human body has to maintain its balance at all times, especially in today’s world when everyone is subjected to extremely hostile and toxic environments. So, what system exists in the body that keeps moods uplifted, pain levels low, inflammation controlled, and appetite in place? The physical and mental health of a person is kept …

Endocannabinoid System 101: The basics of the ECS System Read More »

CBD and CBD oil supplements have been a hot topic in the past 3 years. However, CBD is not legal in many countries and areas. Nutritional brands begin to do more research on anandamide, and hope to use AEA to replace CBD since AEA is naturally occurring in our body, and safe to take. Living …

Best natural FAAH inhibitor supplements to boost anandamide in 2021 Read More »

Are there any anandamide supplements out there? It’s already known that using weed leads to blissful feelings. Studies reveal that THC and CBD bind to cannabinoid receptors, specifically the CB1 and CB2 receptors leading to psychological and physiological outcomes. The CB1 and CB2 receptors make up the body’s endocannabinoid system, aka the ECS. The ECS …

Dietary Supplements that boost anandamide levels in your body Read More »

What Is the Endocannabinoid System? The endocannabinoid system may be defined as a huge network of receptors and enzymes that regulate body homeostasis and other biological functions. Simply put, the endocannabinoid system handles the interaction between cells, including the sending and reception of signals. While it’s less popular in comparison to other systems and cells …

What Is the Endocannabinoid System? Read More »

What Is Anandamide? Anandamide is a neurotransmitter that is released by the brain to stimulate different moods and sensations in the body. The word is coined from Sanskrit, “anand” means pleasure, joy, or bliss. So you can simply say it is a pleasure regulator compound, produced to maintain mood and temperature, activeness, and some other …

Anandamide powder 50%: Everything you need to know about Read More »

Anandamide, known as AEA for short, plays a very important role in neuroprotection through CB1 receptor and CB2 receptor, or CB1/CB2-independent pathways. There are three kinds of popular anandamide analogs on the market, namely methylfluorophosphonate, fatty acid ethanolamides and lipoamino acids. Anandamide analogs have very similar bioactivity and chemical molecule framework as AEA, however their …

Neuroprotective effects of anandamide and its analogs Read More »

Anandamide (= N-arachidonoylethanolamine) is the first discovered endocannabinoid, and belongs to the class of bioactive, long-chain N-acylethanolamines (NAEs). In animal tissues, anandamide is principally formed together with other NAEs from glycerophospholipid by two successive enzymatic reactions: 1) N-acylation of phosphatidylethanolamine to generate N-acylphosphatidylethanolamine (NAPE) by Ca2þ-dependent N-acyltransferase; 2) release of NAE from NAPE by a …

Biosynthetic Pathways of the Endocannabinoid Anandamide Read More »

Introduction Cannabis had many uses as a cultivated plant already in Neolithic China [1]. The first known record of the use of cannabis as a medicine was published in China 5000 years ago in the reign of the Emperor Chen Nung. However, it was not until the 19th century that cannabis became a common medicine …

Discovery and Isolation of Anandamide and Other Endocannabinoids Read More »

ABSTRACT A major finding—that (–)-trans-D9 -tetrahydrocannabinol (D9 -THC) is largely responsible for the psychotropic effects of cannabis—prompted research in the 1970s and 1980s that led to the discovery that this plant cannabinoid acts through at least two types of cannabinoid receptor, CB1 and CB2, and that D9 -THC and other compounds that target either or …

Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond Read More »